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"Disease specific probe is a kind of molecular diagnostic reagent. Specific genes related to specific diseases are labeled with green or orange fluorescence and hybridized with corresponding gene loci. By observing the fluorescent signal points and identify the status of the signal points,the results can provide the basis for the diagnosis, medication guidance and tumor prognosis.
In different tumors, specific genes may have abnormalities, including gene breakage, gene amplification, gene deletion and so on. DNA probes can detect these abnormalities through labeled fluorescent signal points.
There are two kinds of disease-specific probes: monochrome and bicolor. Our FISH probes are more time-saving, specific and anti quenching.
FISH Probe Name |
Marker Site |
FISH Probe Name |
Marker Site |
|
| Non-Small Cell Lung Cancer | Acute Myeloid Leukemia /AML (Non APL) | |||
ALK FISH probe |
2p23.1-23.2 | AML1/ETO FISH probe |
8q21.3-22.1 21q22.11-22.12 |
|
ROS1 FISH probe |
7q31.2 | PML/RARA FISH probe |
15q24.1, 17q21.1-21.2 |
|
MET FISH probe |
7q31.2 | CBFB FISH probe |
16q22.1 | |
KMT2A (MLL) FISH probe |
11q23.3 | |||
| Breast Cancer | CBFB/MYH11 FISH probe |
16q22.1 | ||
| 17q12-21.1 | ||||
| Acute Lymphoblastic Leukemia (ALL) | ||||
| Stomach Cancer | TEL/AML1 FISH probe |
12p13.2, 21q22.11-22.12 |
||
| HER2 FISH probe | 17q12-21.1 | BCR/ABL FISH probe |
9q34.11-13, 22q11.22-23 |
|
IGH FISH probe |
14q32.33 | |||
| Bladder Cancer | P16 FISH probe |
9p21.3 | ||
Bladder cancer FISH probe |
9p21.3 | KMT2A (MLL) FISH probe |
11q23.3 | |
P53 gene probe |
17q13.1 | Chromosomes 4, 10 FISH probe |
centromeric | |
Chromosome 17 FISH probe |
centromeric | |||
| Cervical Cancer | MYC FISH probe |
8q24 | ||
| 3q26.2 | ||||
| Multiple Myeloma (MM) | ||||
| Brain Tumor | RB1 FISH probe |
13q14.2 | ||
7q34 |
1q21 FISH probe |
1q21 | ||
1p/19q FISH probe |
1p36.31, 1q25.3 19q13, 19p13 |
P53 FISH probe |
17q13.1 | |
IGH FISH probe |
14q32.33 | |||
| Lymphoma | CCND1 /IGH FISH probe |
11q13.3；14q32.33 |
||
BCL6 FISH probe |
3q27.3-28 | 13q FISH probe |
13q14.2；13q34 |
|
BCL2 FISH probe |
18q21.33-22.1 | |||
IGH FISH probe |
14q32.33 |
Myelodysplastic Syndrome (MDS) | ||
MYC/IGH FISH |
8q24.21 14q32.33 |
MDS FISH probe |
7q31,20q12,5p15 CEPX.CEPY |
|
BCL2/IGH FISH probe |
18q21.33；14q32.33 |
Chromosome 8 FISH probe |
centromeric | |
P53 gene probe |
17q13.1 | |||
MYC FISH probe |
8q24.21 | Aplastic Anemia | ||
CCND1 /IGH FISH probe |
11q13.3；14q32.33 |
centromeric | ||
7q FISH probe |
7q22.1-22.2；7q31 |
|||
| Chronic Lymphocytic Leukemia (CLL) | 20q FISH probe |
20q12；20q13.12 |
||
CLL FISH probe |
13q14.2, 11q22.3,17q13.1 |
|||
Chromosome 12 FISH Probe |
centromeric | Chronic Myeloid Leukemia (CML) | ||
ATM FISH probe |
11q22.3 | BCR/ABL FISH probe | 9q34.11-13；22q11.22-23 |
|
13q FISH probe |
13q14.2；13q34 |
|||
MYB FISH probe |
6q23.2-23.3 | |||
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